ABSTRACT
The recent rapprochement among China, Iran and Russia reveals the emergence of a new, unexpected, regional strategic triangle with the potential to balance the United States' dominant position. By focusing on the evolution of this strategic triangle in the post-Cold War period, this article investigates the driving forces that bring the three states together, namely the US power and unilateralism as materialised in NATO's eastward expansion, the sanctions on Russia after the annexation of Crimea and the war in Ukraine, the sanctions against Iran, the US trade war with China and the hostile US posture during the coronavirus disease-2019 pandemic. Drawing on soft balancing theory, this article provides an empirical assessment of China–Iran– Russia strategies in countering the US power. Thus, this article aims to fill a gap in the existing literature by investigating this triangular relationship and its balancing potential under the analytic construct of a strategic triangle. Finally, the analysis demonstrates that the three states have employed soft balancing mechanisms, primarily economic strengthening and entangling diplomacy in international institutions. At the same time, territorial denial was sought on various occasions due to the regional importance of this triangular relationship. In conclusion, the article also offers insights into potential hard-balancing behaviour in the long run. © 2023 The Author(s).
ABSTRACT
The recently identified 2019 novel coronaviruses (2019-nCoV) has caused extra-human infections. 2019-nCoV identified a global threat that is causing an outbreak of unusual viral pneumonia in patients with severe acute respiratory syndrome (SARS)-coronaviruses 2 (SARS-CoV-2). Considering the relatively high identity of the receptor-binding domain (RBD) in 2019-nCoV and SARS-CoV, it is urgent to assess the cross-reactivity of anti-SARS-CoV antibodies with 2019-nCoV spike protein, which could have important implications for rapid development of vaccines and therapeutic antibodies against 2019-nCoV. The zinc metallopeptidase angiotensin-converting enzyme 2 (ACE2) is the only known human homolog of the key regulator of blood pressure ACE. ACE2 also serves as the cellular entry point for the SARS virus, therefore, a prime target for pharmacological intervention. SARS-CoV-2 uses the SARS-CoV receptor for entry and the serine protease transmembrane protease serine 2 for spike (S) protein priming. That it is still necessary to develop novel mAbs that could bind specifically to 2019-nCoV RBD. Cell entry of coronaviruses depends on the binding of the viral S proteins to cellular receptors and S protein priming by host cell proteases. A transmembrane protease serine 2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. Our results reveal important commonalities between SARS-CoV-2 and SARS-CoV infection and identify a potential target for antiviral intervention. This review will help understand the biology and potential risk of CoVs that exist in richness in wildlife such as bats. We provide a brief introduction to the pathogenesis of SARS-CoV and Middle East respiratory syndrome-CoV and interaction between the RBD of coronavirus spike protein and ACE2.
ABSTRACT
Background: The clinical and paraclinical symptoms of COVID-19 differ across age groups. This study investigated the differences between these parameters and their outcomes in young, middle-aged, and elderly patients admitted to a COVID-19 referral center. Materials and Methods: This retrospective study encompassed patients with COVID-19 hospitalized at Khorshid Hospital (Isfahan, Iran) during February 23 to April 30, 2020. The patients' predisposing conditions, clinical and paraclinical findings, and outcomes were compared among three young, middle-aged, and elderly groups. Results: Of the 1185 hospitalized patients with suspected COVID-19, 1065 were discharged or died at the end of the study. Among these 1065 patients, 654 patients with the mean age of 57.7 years had positive PCR results or typical CT scans and were included in the study, of whom 77 (11.8%), 353 (54%), and 234 (34.2%) patients were assigned into the young, middle-aged, and elderly groups, respectively. There was no statistically significant difference among the three groups regarding the prevalence of clinical symptoms. Moreover, CRP, ESR, WBC, BUN, Cr, and lymphocytes were higher in the elderly group. The ground-glass opacity (GGO) (24.1%), GGO-consolidation (27.4%), and consolidation (10.3%) were the most common CT scan findings in the young, middle-aged, and elderly groups, respectively. Fifty-three patients (8.1%) died, and the mortality rates were 10.36%, 7.27%, and 3.8% in the elderly, middle-aged, and young groups, respectively. Conclusion: COVID 19 symptoms do not depend on age;however, paraclinical findings differ across young, middle-aged, and elderly patients.
ABSTRACT
Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a new strain of RNA viruses causes coronavirus disease in human. Though some studies suggested different blood group types as risk factors for Coronavirus Disease 2019 (COVID-19) infection, the association between blood groups and the COVID-19 infection may not be the same in various societies with different genetic statuses. Also, no studies so far have investigated the relationship between COVID-19 severity and ABO blood groups in Iran and developing countries according to the World Health Organisation (WHO) criteria. Aim: To evaluate the association between blood types and the severity of COVID-19 infection. Materials and Methods: This cross-sectional study enrolled 171 patients infected with SARS-CoV-2 {49 severe (severe or critical) and 122 non severe (mild to moderate)}, who were admitted to hospitals of Mazandaran University of Medical Sciences, Sari, Iran from April 2020 to June 2020. To evaluate the distribution of the blood group, 171 COVID-19 patients were compared with the reported data of Iranian population blood groups. The severity of COVID-19 infection was determined based on WHO criteria including clinical symptoms, radiological findings, and signs of organ dysfunction. The associations between ABO blood groups and the severity of COVID-19, were evaluated using Pearson's Chi-square. Results: The distribution of the blood group in 171 patients with COVID-19 was not different compared to the reported general Iranian population blood group (p-value=0.344). Evaluation of the association between ABO blood groups and the severity of COVID-19 showed that patients with blood group type B developed severe COVID-19 infection compared to other blood types who showed mild or moderate conditions (p-value=0.048). Mortality due to COVID-19 was not statistically different between the ABO blood group and Rh (p-value=0.96, p-value=0.27 respectively), but the frequency of patients with Rh-negative that needed intubation and mechanical ventilation was higher compared to Rh-positive patients (p-value=0.003). Conclusion: A positive correlation was found between blood type B and COVID-19 severity. Also, mechanical ventilation was significantly more in Rh-negative patients.
ABSTRACT
The present research investigates the effect of self-regulatory strategy instruction on Iranian EFL learners' metadiscoursal writing abilities. To this purpose, 50 Iranian EFL intermediate learners were all native speakers of the Persian language learning the English language in an institute were selected via convenience random sampling. Self-regulated Strategies Intervention and Metadiscoursal writing pretest and post-test were the research instruments employed to collect the data. Because of the circumstance of Covid-19, the instructor made a new WhatsApp group apart from the virtual group, namely Adobe Connect, to make contact with the students. The learners were required to take a metadiscoursal writing pretest. After passing six sessions, intervention through self-regulated strategies was taught, and the participants were required to follow the guidelines. The instructor checked every single learner's progress. Ultimately, they took a post-test. The findings revealed that the self-regulatory strategy significantly impacted Iranian EFL learners' metadiscoursal writing skills. In conclusion, the results indicated that it could be suitable for teachers to gain more information regarding the self-regulated strategy and utilize it, where necessary, for its positive results. © 2021 European Knowledge Development (EUROKD). All right reserved.